Hydrochloric Acid → Zolpidem hydrochloride

HRID 1066184

反応式

HRID 1066184 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:16]=[C:15]3[N:10]([CH:11]=[C:12]([CH3:17])[CH:13]=[CH:14]3)[C:9]=2[CH2:18][C:19]([N:21]([CH3:23])[CH3:22])=[O:20])=[CH:6][CH:7]=1.[ClH:24]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]=[C:15]3[N:10]([CH:11]=[C:12]([CH3:17])[CH:13]=[CH:14]3)[C:9]=2[CH2:18][C:19]([N:21]([CH3:22])[CH3:23])=[O:20])=[CH:4][CH:3]=1.[ClH:24]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 5732Zolpidem

生成物 1

HCID 18004031Zolpidem hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

Zolpidem free base (1.0 g) is suspended in 10 ml of ethanol and heated at 50° C. until dissolution. Then, 0.32 g (molar equivalent) of concentrated hydrochloric acid is added and the solution stirred for 10 minutes. Then the bath is removed and the reaction mixture is allowed to cool to room temperature. Finally, the mixture is kept standing overnight at 4° C. The formed crystals are filtered off, washed with 3 ml of cold ethanol and dried at 40° C. in a vacuum oven to produce zolpidem hydrochloride hemiethanolate.

後処理

  1. customThen the bath is removed
  2. temperatureto cool to room temperature
  3. waitFinally, the mixture is kept standing overnight at 4° C
  4. filtrationThe formed crystals are filtered off
  5. washwashed with 3 ml of cold ethanol
  6. customdried at 40° C. in a vacuum oven

出典と根拠

ORDレコード
ord-b0b0e4102bd547e1a655f8aeafa12160
出典データセット
uspto-grants-2001_06
特許番号
US06242460B1

関連ノート

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