(3-Amino-4-methylphenyl)methanol → N-(5-Hydroxymethyl-2-methylphenyl)-tricyclo[3.3.1.13,7]decane-1-acetamide

HRID 1066251

反応式

HRID 1066251 の反応式
[C:1]12([CH2:11][C:12](Cl)=[O:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH2:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[CH3:24])[CH2:19][OH:20]>>[OH:20][CH2:19][C:18]1[CH:21]=[CH:22][C:23]([CH3:24])=[C:16]([NH:15][C:12](=[O:13])[CH2:11][C:1]23[CH2:10][CH:5]4[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]4)[CH2:2]2)[CH2:8]3)[CH:17]=1

参加物

3

反応物 2

HCID 586243(3-Amino-4-methylphenyl)methanolHCID 27718821-Adamantaneacetyl chloride

生成物 1

HCID 20660024N-(5-Hydroxymethyl-2-methylphenyl)-tricyclo[3.3.1.13,7]decane-1-acetamide収率 37.3%

実験手順

Prepared according to the method of Example 1b) from 1-adamantaneacetyl chloride (2.0 g) and 3-amino4-methylbenzyl alcohol (1.29 g). Silica gel chromatography, eluting with 5% ethylacetate in dichloromethane gave the title compound as a white solid (1.10 g).

後処理

  1. customPrepared
  2. washSilica gel chromatography, eluting with 5% ethylacetate in dichloromethane

出典と根拠

ORDレコード
ord-f25aab50032645d3957dc2962eedf142
出典データセット
uspto-grants-2001_06
特許番号
US06242470B1

関連ノート

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