Sulfuric Acid → Methyl 2-[(acetyloxy)methyl]-3-phenylprop-2-enoate

HRID 1066453ノート

反応式

HRID 1066453 の反応式
O[CH:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3](=[CH2:8])[C:4]([O:6][CH3:7])=[O:5].[C:15]([O:18]C(=O)C)(=[O:17])[CH3:16].S(=O)(=O)(O)O>>[CH:2](=[C:3]([CH2:8][O:18][C:15](=[O:17])[CH3:16])[C:4]([O:6][CH3:7])=[O:5])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 9942369Methyl 3-Hydroxy-2-methylene-3-phenylpropionate

生成物 1

HCID 53678280Methyl 2-[(acetyloxy)methyl]-3-phenylprop-2-enoate収率 110.8%

反応条件

温度
100 °C

実験手順

Methyl 3-hydroxy-2-methylene-3-phenylpropionate (100.6 g, 523 mmols) obtained in Example 5 was dissolved in 113 ml (1.20 mols) of acetic anhydride, and 0.2 ml of sulfuric acid were added thereto. The mixture was stirred at 100° C. for 4 hours. After the completion of the reaction, the reaction solution was concentrated under reduced pressure to obtain 135.7 g of a crude product of the above title compound.

後処理

  1. customAfter the completion of the reaction
  2. concentrationthe reaction solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-31baca4fdd704ff3a4e03e7e28b74b9b
出典データセット
uspto-grants-2001_06
特許番号
US06242635B1

反応ノート

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