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Potassium Iodide → [1,1'-Biphenyl]-4-carbonitrile, 4'-(decyloxy)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | 1-Bromodecane | HCID 8173 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4'-Hydroxy-4-biphenylcarbonitrile | HCID 140610 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | [1,1'-Biphenyl]-4-carbonitrile, 4'-(decyloxy)- | HCID 112405 | — |
反応手順
A mixture of 4-cyano-4′-hydroxybiphenyl (56) (10.10 g, 0.052 mol), 1-bromodecane (14.38 g, 0.065 mol), anhydrous potassium carbonate (37.32 g, 0.27 mol), butanone (300 ml) and a trace of potassium iodide was heated under reflux overnight. The cooled solution was filtered to remove inorganic salts and the solvent was removed in vacuo. The residual oil was distilled (to remove excess bromide) and finally purified by column chromatography (dichloromethane) to yield a colourless, low melting solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06242636B1 |
| 出典データセット | uspto-grants-2001_06 |
| ORD ID | ord-ea967d401430401aabcbd2daa2c4c497 |
| 出典メモ | uspto-grants-2001_06 |