Diethyl Ether → 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide

HRID 1066646ノート

反応式

HRID 1066646 の反応式
[Br:1]Br.[BrH:3].[C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)(=[O:6])[CH3:5].CCOCC>C(Cl)Cl>[BrH:1].[Br:3][CH2:5][C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)=[O:6]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 212004624-Acetyl-4-phenylpiperidine hydrobromide

生成物 1

HCID 227417564-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide収率 93.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

7.9 g of bromine are added rapidly at RT to a suspension of 14 g of 4-acetyl-4-phenylpiperidine hydrobromide in 200 ml of DCM and the reaction mixture is stirred overnight at RT. It is diluted by the addition of 200 ml of ether and the precipitate formed is wrung and washed with ether to give 16.7 g of the expected product after drying under vacuum.

後処理

  1. customthe precipitate formed
  2. washwashed with ether

出典と根拠

ORDレコード
ord-e00921bfd75e4c38a3e801d76412bc7d
出典データセット
uspto-grants-2001_06
特許番号
US06242637B1

反応ノート

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