Potassium Hydroxide → 5-Bromo-7-chloroindoline

HRID 1066753ノート

反応式

HRID 1066753 の反応式
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([Br:14])=[CH:10][C:11]=2[Cl:13])[CH2:6][CH2:5]1)(=O)C.[OH-].[K+]>C(O)C.O>[Br:14][C:9]1[CH:8]=[C:7]2[C:12](=[C:11]([Cl:13])[CH:10]=1)[NH:4][CH2:5][CH2:6]2

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 186292691-(5-Bromo-7-chloro-2,3-dihydro-1H-indol-1-yl)ethan-1-one

生成物 1

HCID 167891645-Bromo-7-chloroindoline収率 87.8%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

1-acetyl-5-bromo-7-chloroindoline (1.17 g) was dissolved in a mixture of ethanol (15 mL) and water (8 mL) containing KOH (0.5 g) and heated to reflux for 2 h. The reaction was partitioned between EtOAc (100 mL) and water (20 mL). The organic extract was washed with brine (20 mL), dried and stripped in vacuo to give 5-bromo-7-chloroindoline (0.87 g).

後処理

  1. temperatureheated
  2. temperatureto reflux for 2 h
  3. customThe reaction was partitioned between EtOAc (100 mL) and water (20 mL)
  4. extractionThe organic extract
  5. washwas washed with brine (20 mL)
  6. customdried

出典と根拠

ORDレコード
ord-6e95cf2cdc4e414d89a1fafa79036668
出典データセット
uspto-grants-2001_06
特許番号
US06245769B1

反応ノート

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