Carbon tetrabromide → 2-(Bromomethyl)-4-chloro-1-fluorobenzene
反応式
[F:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH2:4]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:31]>C(OCC)C>[F:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH2:4][Br:31]参加物
5
実験手順
A solution of 2-fluoro-5-chlorobenzyl alcohol (1.28 g, 7.97 mmol) in diethyl ether (26 ml) was treated with triphenylphosphine (2.72 g, 10.36 mmol), followed by carbon tetrabromide (3.44 g, 10.36 mmol). The resultant suspension was stirred for 3.5 hours, then filtered, washing with diethyl ether. The filtrate was concentrated, then passed through a plug of silica to remove triphenylphosphate. The residue was then purified by liquid chromatography affording 2.0 grams of a clear oil.
後処理
- filtrationfiltered
- washwashing with diethyl ether
- concentrationThe filtrate was concentrated
- customto remove triphenylphosphate
- customThe residue was then purified by liquid chromatography
出典と根拠
- ORDレコード
- ord-276ce778c1a84462b18a055612b46bc5
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06245761B1
反応ノート
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