Carbon tetrabromide → HCID 21196139、化合物

HRID 1066829ノート

反応式

HRID 1066829 の反応式
[F:1][C:2]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:36]>C(OCC)C>[F:1][C:2]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9][Br:36]

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 211961624-(2-Fluoro-5-bromobenzyloxy)butanol

生成物 1

HCID 21196139HCID 21196139、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of 4-(2-fluoro-5-bromobenzyloxy)butanol (7.03 g, 26.3 mmol) in diethyl ether (88 ml) was treated with triphenylphosphine (8.97 g, 34.2 mmol) and carbon tetrabromide (11.3 g, 34.2 mmol). The cloudy solution was stirred at ambient temperature for about 30 hours. The precipitate was removed by filtration and the filtrate was concentrated. The desired title intermediate was purified from the filtrate by bulb to bulb distillation.

後処理

  1. customThe precipitate was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. distillationThe desired title intermediate was purified from the filtrate by bulb to bulb distillation

出典と根拠

ORDレコード
ord-08bfffead2d44ba6b108f68f28ad0cfc
出典データセット
uspto-grants-2001_06
特許番号
US06245761B1

反応ノート

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