Urea → Carbamazepine

HRID 1067029

反応式

HRID 1067029 の反応式
[NH2:1][C:2]([NH2:4])=[O:3].[CH:5]1[CH:6]=[CH:7][C:8]2N[C:18]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH:12]=[CH:11][C:9]=2[CH:10]=1>C(O)(=O)C.P(=O)(O)(O)O>[CH:5]1[CH:6]=[CH:7][C:8]2[N:1]([C:2]([NH2:4])=[O:3])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[CH:12]=[CH:11][C:9]=2[CH:10]=1

参加物

5

反応物 2

HCID 1176UreaHCID 9212Dibenz(b,f)azepine

生成物 1

HCID 2554Carbamazepine

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 1004Phosphoric Acid溶媒

反応条件

温度
27.5 °C

実験手順

To a suspension of urea (80 g, 1.333 mols) in acetic acid (100 ml), phosphoric acid (8 ml) was added, followed by iminostilbene (20 g, 0.103 mols), under stirring at 25-30° C. The resulting reaction mixture was worked up according to the method of Example 1 to produce carbamazepine, which was identical to the product of Example 1.

後処理

  1. additionwas added
  2. customThe resulting reaction mixture

出典と根拠

ORDレコード
ord-4ac90fca99bf43eb8cf1417bbe33bd96
出典データセット
uspto-grants-2001_06
特許番号
US06245908B1

関連ノート

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