Urea → Carbamazepine

HRID 1067030

反応式

HRID 1067030 の反応式
[NH2:1][C:2]([NH2:4])=[O:3].Cl.N=[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]1[CH:13]=[CH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(O)(=O)C>[CH:10]1[CH:11]=[CH:12][C:7]2[N:1]([C:2]([NH2:4])=[O:3])[C:20]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[CH:14]=[CH:13][C:8]=2[CH:9]=1

参加物

4

反応物 2

HCID 1176UreaHCID 86757001HCID 86757001、化合物

生成物 1

HCID 2554Carbamazepine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
27.5 °C

実験手順

To a suspension of urea (80 g, 1.333 mols) in acetic acid (100 ml), iminostilbene hydrochloride (20.5 g, 0.089 mols) was added under stirring at 25-30° C. The resulting reaction mixture was worked up according to the method of Example 1 to produce carbamazepine, which was identical to the product of Example 1.

後処理

  1. additionwas added
  2. customThe resulting reaction mixture

出典と根拠

ORDレコード
ord-f28b1fba312342719ceac64444cc2f77
出典データセット
uspto-grants-2001_06
特許番号
US06245908B1

関連ノート

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