Dibenz(b,f)azepine → Carbamazepine

HRID 1067031

反応式

HRID 1067031 の反応式
Cl.[NH2:2][C:3]([NH2:5])=[O:4].[CH:6]1[CH:7]=[CH:8][C:9]2N[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH:13]=[CH:12][C:10]=2[CH:11]=1>C(O)(=O)C>[CH:6]1[CH:7]=[CH:8][C:9]2[N:2]([C:3]([NH2:5])=[O:4])[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[CH:13]=[CH:12][C:10]=2[CH:11]=1

参加物

4

反応物 2

HCID 9212Dibenz(b,f)azepineHCID 101721Urea hydrochloride

生成物 1

HCID 2554Carbamazepine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
27.5 °C

実験手順

To a suspension of urea hydrochloride (100 g, 1.036 mols) in acetic acid (125 ml), iminostilbene (25 g, 0.129 mols) was added under stirring at 25-30° C. The resulting reaction mixture was worked up according to the method of Example 1 to produce carbamazepine, which was identical to the product of Example 1.

後処理

  1. additionwas added
  2. customThe resulting reaction mixture

出典と根拠

ORDレコード
ord-8e4456a22a7f49ce952b44e08861db61
出典データセット
uspto-grants-2001_06
特許番号
US06245908B1

関連ノート

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