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Triethylamine → N,N,N',N'-Tetrakis[2-(benzyloxycarbonylamino)-ethyl]-5-nitro-isophthalic acid-diamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-Nitroisophthaloyl chloride | HCID 83451 | — |
| 反応物 | N,N''-Di-Z-diethylenetriamine | HCID 4367374 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N,N,N',N'-Tetrakis[2-(benzyloxycarbonylamino)-ethyl]-5-nitro-isophthalic acid-diamide | HCID 17909256 | — |
反応手順
14.86 g (40 mmol) of the bis[2-(benzyloxycarbonylamino)-ethyl]-amine described in Example 1a and 20.24 g (200 mmol) of triethylamine are dissolved in dimethylformamide and mixed with 4.96 g (20 mmol) of 5-nitro-isophthalic acid dichloride (J. Chem. Soc. 1957, 1172-1175) and stirred overnight at room temperature. The solution is concentrated by evaporation in a vacuum and the residue is chromatographed with ethyl acetate on silica gel.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06248306B1 |
| 出典データセット | uspto-grants-2001_06 |
| ORD ID | ord-51fe1b4e2e1f42c685f7064504a78e2b |
| 出典メモ | uspto-grants-2001_06 |