Ammonia → 1,4-Dichloro-7-sulphamoylisoquinoline

HRID 1067244ノート

反応式

HRID 1067244 の反応式
Cl[S:2]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([Cl:16])=[CH:10][N:11]=[C:12]2[Cl:15])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH3:17]>>[Cl:15][C:12]1[C:13]2[C:8](=[CH:7][CH:6]=[C:5]([S:2](=[O:4])(=[O:3])[NH2:17])[CH:14]=2)[C:9]([Cl:16])=[CH:10][N:11]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 166582941,4-Dichloroisoquinoline-7-sulfonyl chloride

生成物 1

HCID 166586321,4-Dichloro-7-sulphamoylisoquinoline

実験手順

7-chlorosulphonyl-1,4-dichloroisoquinoline (110 mg, 0.37 mmol) was dissolved in a solution of saturated methanolic ammonia (NH3) (10 mL) and the solution stirred at room temperature for 1.5 hours. The solvents were evaporated in vacuo and the residue was azeotroped with CH2Cl2 and then partitioned between EtOAc and water. The organic phase was washed with brine, dried (MgSO4) and evaporated in vacuo to give 1,4-dichloro-7-sulphamoylisoquinoline (98 mg, 0.35 mmol) as a white solid.

後処理

  1. customThe solvents were evaporated in vacuo
  2. customthe residue was azeotroped with CH2Cl2
  3. custompartitioned between EtOAc and water
  4. washThe organic phase was washed with brine
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-2cafeccf2f0a4c2499c528193bf31747
出典データセット
uspto-grants-2001_06
特許番号
US06248738B1

反応ノート

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