Tert-Butyl nitrite → HCID 23445659、化合物

HRID 1067358ノート

反応式

HRID 1067358 の反応式
[Br:1][C:2]1[CH:8]=[C:7]([CH2:9][CH3:10])[C:5]([NH2:6])=[C:4]([CH2:11][CH3:12])[CH:3]=1.[F:13][B-:14]([F:17])([F:16])[F:15].[H+].[N:19](OC(C)(C)C)=O>C(O)C>[F:13][B-:14]([F:17])([F:16])[F:15].[Br:1][C:2]1[CH:8]=[C:7]([CH2:9][CH3:10])[C:5]([N+:6]#[N:19])=[C:4]([CH2:11][CH3:12])[CH:3]=1

参加物

5

反応物 3

HCID 10906Tert-Butyl nitriteHCID 28118Tetrafluoroboric acidHCID 6114524-Bromo-2,6-diethylaniline

生成物 1

HCID 23445659HCID 23445659、化合物収率 66%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

At 0° C., to a stirred solution of commercial 4-bromo-2,6-diethylaniline (10.0 g, 43.9 mmol) in absolute ethanol (219 mL) was added 48% aq. tetrafluoroboric acid (17.2 mL), followed by tert-butyl nitrite (5.7 mL, 48.0 mmol). After 0.5 h, the reaction was poured into ice cold ether (877 mL). The resulting precipitate was washed with cold ether and dried to give 9.39 g (66%) of the title compound. 1H NMR: consistent.

後処理

  1. washThe resulting precipitate was washed with cold ether
  2. customdried

出典と根拠

ORDレコード
ord-b8e222e004b5461f856955c16ca5661e
出典データセット
uspto-grants-2001_06
特許番号
US06248764B1

反応ノート

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