Phenylacetonitrile → 2-Phenylethanethioamide

HRID 1067416

反応式

HRID 1067416 の反応式
[C:1]1([CH2:7][C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P([O-])(OCC)(SCC)=[S:11]>Cl.C(OCC)(=O)C>[C:1]1([CH2:7][C:8]([NH2:9])=[S:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 8794PhenylacetonitrileHCID 53249491Diethyldithiophosphate

生成物 1

HCID 7313682-Phenylethanethioamide収率 55%

試薬・触媒・溶媒 1

HCID 21866389Hydrogen chloride-ethyl acetate溶媒

実験手順

A solution of phenylacetonitrile (10.0 g, 85.4 mmol) and diethyl dithiophosphate (17.5 g, 93.9 mmol) in 4N-HCl/ethyl acetate (400 mL) was stirred at room temperature for 16 hours. This reaction mixture was washed with water and saturated aqueous sodium hydrogen carbonate solution, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was crystallized from ethanol to provide 7.1 g of the title compound. Yield 55%.

後処理

  1. washThis reaction mixture was washed with water and saturated aqueous sodium hydrogen carbonate solution
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was crystallized from ethanol

出典と根拠

ORDレコード
ord-b95e9b3ac9114e76baa3b07b56de8fcd
出典データセット
uspto-grants-2001_06
特許番号
US06248766B1

関連ノート

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