C([O:3][C:4](=[O:21])[CH2:5][O:6][C:7]1[CH:20]=[C:19]2[C:10]([CH2:11][CH2:12][C:13]3[S:17][C:16]([SH:18])=[N:15][C:14]=32)=[CH:9][CH:8]=1)C.[C:22]1([CH:28]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:29]I)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:22]1([CH:28]([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:29][S:18][C:16]2[S:17][C:13]3[CH2:12][CH2:11][C:10]4[C:19](=[CH:20][C:7]([O:6][CH2:5][C:4]([OH:3])=[O:21])=[CH:8][CH:9]=4)[C:14]=3[N:15]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1Using ethyl[(2-mercapto-4,5-dihydronaphtho[1,2-d]thiazol-8-yl)oxy]acetate and 2,2-diphenylethyl iodide, the procedure of Example 21 was otherwise repeated to synthesize the title compound. Yield 69%.
読み込み中…