Ethyl cyanoacetate → 2-cyano-N-[3-(dimethylamino)propyl]acetamide
反応式
[C:1]([CH2:3][C:4]([O:6]CC)=O)#[N:2].[CH3:9][N:10]([CH3:15])[CH2:11][CH2:12][CH2:13][NH2:14]>C1(C)C=CC=CC=1>[C:1]([CH2:3][C:4]([NH:14][CH2:13][CH2:12][CH2:11][N:10]([CH3:15])[CH3:9])=[O:6])#[N:2]参加物
4
実験手順
Ethyl cyanoacetate (51.106 g, 0.4518 mole) was added to 3-(dimethylamino) propylamine (46.162 g, 0.4518 mole) in a 250 ml round bottom flask equipped with a magnetic stir bar. After stirring for approximately 0.5 hr, 50 ml of toluene was added. The clear orange liquid was stirred at room temperature for approximately 15 hours, after which the ethanol and toluene were removed via vacuum distillation. 2-Cyano-N-[3-(dimethylamino)propyl]acetamide was obtained in 96% yield.
後処理
- customequipped with a magnetic stir bar
- stirringThe clear orange liquid was stirred at room temperature for approximately 15 hours
- customafter which the ethanol and toluene were removed via vacuum distillation
出典と根拠
- ORDレコード
- ord-433b1c351aab4497821ec99175586d5b
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06248801B1
反応ノート
読み込み中…