Potassium Hydroxide → 2-(Piperidin-4-yl)-1,3-benzothiazole

HRID 1068142ノート

反応式

HRID 1068142 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]1[CH2:15][CH2:14][N:13](C(=O)C)[CH2:12][CH2:11]1.[OH-].[K+]>CO>[NH:13]1[CH2:12][CH2:11][CH:10]([C:2]2[S:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)[CH2:15][CH2:14]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 92186951-(4-(Benzo[d]thiazol-2-yl)piperidin-1-yl)ethanone

生成物 1

HCID 14774392-(Piperidin-4-yl)-1,3-benzothiazole収率 46%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 1.4 g of 1-(4-(benzothiazol-2-yl)piperidin-1-yl)ethanone in 10 mL of MeOH was added 7.5 mL of KOH (45 wt. % solution). After refluxing for 18 hours, the reaction was cooled to room temperature. The mixture was partitioned between EtOAc and water. The organic phase was washed with brine and dried over MgSO4. Concentration under reduced pressure gave 540 mg of the title compound as a solid.

後処理

  1. temperatureAfter refluxing for 18 hours
  2. customThe mixture was partitioned between EtOAc and water
  3. washThe organic phase was washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationConcentration under reduced pressure

出典と根拠

ORDレコード
ord-d0be67bac92b4883aa6f514c01c77427
出典データセット
uspto-grants-2001_06
特許番号
US06248755B1

反応ノート

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