Methyl methylthiosulphonate → 5-Chloro-n-(methylthio)-n-2-propenyl-3-(trimethylsilyl)-2-thiophenecarboxamide
反応式
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH2:10][CH:11]=[CH2:12])=[O:8])=[C:4]([Si:13]([CH3:16])([CH3:15])[CH3:14])[CH:3]=1.[CH3:17][S:18](=S)(OC)=O.C(N(SC)C(C1SC=CC=1[Si](C)(C)C)=O)C>>[Cl:1][C:2]1[S:6][C:5]([C:7]([N:9]([S:18][CH3:17])[CH2:10][CH:11]=[CH2:12])=[O:8])=[C:4]([Si:13]([CH3:14])([CH3:16])[CH3:15])[CH:3]=1参加物
4
実験手順
The compound of Example 262 (1.1 g) was reacted with 0.52 g of methyl methanethiosulfonate using procedure described for the preparation of the compound of Example 272. The title compound (0.6 g) was purified by flash chromatography with 2% ethyl acetate-hexane and recovered as a colorless oil. nD25 1.5698.
後処理
- customThe title compound (0.6 g) was purified by flash chromatography with 2% ethyl acetate-hexane
- customrecovered as a colorless oil
出典と根拠
- ORDレコード
- ord-d06579688a09407abf12a7ad9ef94718
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06248894B1
反応ノート
読み込み中…