Hydrochloric Acid → 1-[4-(Amino)butan-1-yl]-1,2-dihydro-1,4,7b-triazacyclopent[cd]inden-2-one-dihydrochloride
反応式
[NH:1]1[C:9]2[N:4]3[C:5](=[N:10][CH:11]=[C:3]3[C:2]1=[O:12])[CH:6]=[CH:7][CH:8]=2.[ClH:13]>CO>[ClH:13].[ClH:13].[NH2:1][CH2:9][CH2:8][CH2:7][CH2:6][N:1]1[C:9]2[N:4]3[C:5](=[N:10][CH:11]=[C:3]3[C:2]1=[O:12])[CH:6]=[CH:7][CH:8]=2参加物
4
実験手順
To a solution of 548 mg (1.66 mmol) of 1-[4-tert-butoxycarbonylamino)butan-1-yl]-1,2-dihydro-1,4,7b-triazacyclopent[cd]inden-2-one in 10 ml of methanol was added dropwise 10 ml of conc. HCl. The mixture was stirred for one hour at room temperature. The solvent was distilled off. To the residue was added acetone. The resulting solid was collected by filtration and washed with acetone to give 400 mg of the desired compound (79.5%, grayish white solid).
後処理
- distillationThe solvent was distilled off
- additionTo the residue was added acetone
- filtrationThe resulting solid was collected by filtration
- washwashed with acetone
出典と根拠
- ORDレコード
- ord-6471abc93b1e4222bf3d70dda429d0b6
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06251905B1
反応ノート
読み込み中…