Dimethylformamide → HCID 21190779、化合物
反応式
CN(C=O)C.O=[C:7]1[CH2:12][CH2:11][CH:10]([N:13]2[C:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([O:24][CH3:25])[N:19]=3)=[C:16]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[N:15]=[CH:14]2)[CH2:9][CH2:8]1>CCOCC>[CH:10]1([N:13]2[C:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([O:24][CH3:25])[N:19]=3)=[C:16]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[N:15]=[CH:14]2)[CH2:9][CH2:8][CH2:7][CH2:12][CH2:11]1参加物
4
実験手順
The product of the preceding example, DMF (10 mL), the product of example 1 (b) (1.59 g, 5.5 mmol) and KCO3 (0.308 g, 2.23 mmol) were combined and stirred for 2 days, diluted with Et2O and filtered. The filtrate was concentrated under high vacuum to a brown paste. Trituration with Et2O and hexane (1:1, 200 mL) afforded the title compound as a tan solid. Crystallization from EtOAc/hexane (1:4) afforded 0.631 g (39% from the product of example 1(d). ESP+ (Mass Spec) m/z 353 (MH+). mp=207-208.