Acetic Anhydride → 3-(4-acetyl-piperazin-1-yl)-4-(3-chlorophenylamino)-1H-pyrazolo(3,4-d]pyrimidine

HRID 1068895ノート

反応式

HRID 1068895 の反応式
Cl.Cl.[Cl:3][C:4]1[CH:5]=[C:6]([NH:10][C:11]2[N:16]=[CH:15][N:14]=[C:13]3[NH:17][N:18]=[C:19]([N:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[C:12]=23)[CH:7]=[CH:8][CH:9]=1.C(=O)([O-])[O-].[K+].[K+].[C:32](OC(=O)C)(=[O:34])[CH3:33]>O.O1CCOCC1>[C:32]([N:23]1[CH2:24][CH2:25][N:20]([C:19]2[C:12]3[C:13](=[N:14][CH:15]=[N:16][C:11]=3[NH:10][C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([Cl:3])[CH:5]=3)[NH:17][N:18]=2)[CH2:21][CH2:22]1)(=[O:34])[CH3:33]

参加物

6

反応物 3

HCID 7918Acetic AnhydrideHCID 11430Potassium CarbonateHCID 211906574-(3-chlorophenylamino)-3-(piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine dihydrochloride

生成物 1

HCID 211906143-(4-acetyl-piperazin-1-yl)-4-(3-chlorophenylamino)-1H-pyrazolo(3,4-d]pyrimidine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

Analogously to Example 26, 100 mg (0.248 mmol) of 4-(3-chlorophenylamino)-3-(piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine dihydrochloride and 103 mg (0.74 mmol) of potassium carbonate in 10 ml of water are reacted with 38 mg (0.37 mmol) of acetic anhydride in 10 ml of dioxane to form 3-(4-acetyl-piperazin-1-yl)-4-(3-chlorophenylamino)-1H-pyrazolo(3,4-d]pyrimidine; HPLC: tRet(grad20-100/20)=10.8; FAB-MS: (M+H)+=372.

出典と根拠

ORDレコード
ord-effaed7608984701b4800ccc1e7cd7b5
出典データセット
uspto-grants-2001_06
特許番号
US06251911B1

反応ノート

読み込み中…