Sodium Acetate → HCID 2910222、化合物

HRID 1069125

反応式

HRID 1069125 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=1.C([O-])(=O)C.[Na+].[S:24]1[CH2:30][C:28](=[O:29])[NH:27][C:25]1=[S:26]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[C:30]2[S:24][C:25](=[S:26])[NH:27][C:28]2=[O:29])=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 517045Sodium AcetateHCID 7354674-[(2-Chloro-6-fluorophenyl)methoxy]benzaldehydeHCID 1201546Rhodanine

生成物 1

HCID 2910222HCID 2910222、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Under a nitrogen atmosphere in a round bottom flask 4-[(2-chloro-6-fluorophenyl)methoxy]benzaldehyde (1.00 g, 3.78 mmol) was dissolved in acetic acid (19 ml). To this solution was added sodium acetate (1.08 g, 13.2 mmol) and then rhodanine (0.50 g, 3.75 mmol). The reaction mixture was then heated to reflux and maintained at this temeprature. The progress of the reaction was monitored by thin layer chromatography.

後処理

  1. temperatureThe reaction mixture was then heated
  2. temperatureto reflux
  3. temperaturemaintained at this temeprature

出典と根拠

ORDレコード
ord-ff225fa8a1734b3aa2a98ab3e16d0410
出典データセット
uspto-grants-2001_06
特許番号
US06251928B1

関連ノート

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