Hydrazine → 1-(3-aminobutyl)-4-chloro-5-methyl-1H-pyrrole-2-carbonitrile
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:23]#[N:24])[N:5]([CH2:8][CH2:9][CH:10]([N:12]2C(=O)C3C(=CC=CC=3)C2=O)[CH3:11])[C:6]=1[CH3:7].NN>C(O)C>[NH2:12][CH:10]([CH3:11])[CH2:9][CH2:8][N:5]1[C:6]([CH3:7])=[C:2]([Cl:1])[CH:3]=[C:4]1[C:23]#[N:24]参加物
4
実験手順
A solution of 3.2 g (9.4 mmol) of 4-chloro-1-[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl]-5-methyl-1H-pyrrole-2-carbonitrile and 4.8 mL (94 mmol) of hydrazine in ethanol was heated at reflux for 60 min and cooled to room temperature. Precipitated solids were filtered and rinsed with ethyl acetate and the filtrate was concentrated to afford 1-(3-aminobutyl)-4-chloro-5-methyl-1H-pyrrole-2-carbonitrile as an oil. Step D: Preparation of 2-cyano-3,4,4-trimethylpentanoic acid
後処理
- temperatureat reflux for 60 min
- customPrecipitated solids
- filtrationwere filtered
- washrinsed with ethyl acetate
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-00dfc117e26848d8b4ccfc89ef271880
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06251947B1
反応ノート
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