2-Bromoethanol → 2-{[(1R)-1-phenylethyl]amino}ethan-1-ol

HRID 1069402ノート

反応式

HRID 1069402 の反応式
[CH3:1][C@@H:2]([NH2:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:11][CH2:12][OH:13]>ClCCl>[OH:13][CH2:12][CH2:11][NH:9][C@H:2]([CH3:1])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 108982-BromoethanolHCID 6431891-Phenethylamine, (+)-

生成物 1

HCID 69938212-{[(1R)-1-phenylethyl]amino}ethan-1-ol収率 76,003%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
51 °C

実験手順

51.45 g (0.43 mmole) of (R)-(+)-α-methylbenzylamine was dissolved in 52 ml of dichloromethane and 63.78 g (0.51 mmole) of 2-bromoethanol was added thereto. This mixture was stirred at 51° C. for 50 hours to complete the reaction. The reaction solution was concentrated under reduced pressure and the residue was subjected to fractional distillation to obtain 54 g of the title compound having pale yellow color.

後処理

  1. customthe reaction
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. distillationthe residue was subjected to fractional distillation

出典と根拠

ORDレコード
ord-f52640b0735f4828a029802ddd5ff12a
出典データセット
uspto-grants-2001_06
特許番号
US06252076B1

反応ノート

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