Hydrochloric Acid → (s)-(z)-5-[[5-Fluoro-2-oxo-4-[(pyrrolidin-2-yl)ethynyl]-1,2-dihydro-indol-3-ylidene]methyl]-4-methyl-1h-pyrrole-3-carboxylic acid ethyl ester hydrochloride salt

HRID 1069784ノート

反応式

HRID 1069784 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:10]([CH3:11])=[C:9](/[CH:12]=[C:13]2\[C:14](=[O:30])[NH:15][C:16]3[C:21]\2=[C:20]([C:22]#[C:23][C@@H:24]2[CH2:28][CH2:27][CH2:26][NH:25]2)[C:19]([F:29])=[CH:18][CH:17]=3)[NH:8][CH:7]=1)=[O:5])[CH3:2].[ClH:31]>O1CCOCC1>[ClH:31].[CH2:1]([O:3][C:4]([C:6]1[C:10]([CH3:11])=[C:9](/[CH:12]=[C:13]2\[C:14](=[O:30])[NH:15][C:16]3[C:21]\2=[C:20]([C:22]#[C:23][C@@H:24]2[CH2:28][CH2:27][CH2:26][NH:25]2)[C:19]([F:29])=[CH:18][CH:17]=3)[NH:8][CH:7]=1)=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 15907936(S)-(Z)-5-[[5-Fluoro-2-oxo-4-[(pyrrolidin-2-yl)ethynyl]-1,2-dihydro-indol-3-ylidene]methyl]-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

生成物 1

HCID 69948456(s)-(z)-5-[[5-Fluoro-2-oxo-4-[(pyrrolidin-2-yl)ethynyl]-1,2-dihydro-indol-3-ylidene]methyl]-4-methyl-1h-pyrrole-3-carboxylic acid ethyl ester hydrochloride salt

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A solution of (S)-(Z)-5-[[5-Fluoro-2-oxo-4-[(pyrrolidin-2-yl)ethynyl]-1,2-dihydro-indol-3-ylidene]methyl]-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester (14 mg, 0.03 mmol) (from Example 121 above) in dioxane (10 mL) was treated with aqueous HCl under vigorous stirring. (S)-(Z)-5-[[5-Fluoro-2-oxo-4-[(pyrrolidin-2-yl)ethynyl]-1,2-dihydro-indol-3-ylidene]methyl]-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester hydrochloride salt was obtained upon lyophilization. (Yield 12 mg, 79%).

出典と根拠

ORDレコード
ord-55b4529ad25847ca98af772090262a73
出典データセット
uspto-grants-2001_06
特許番号
US06252086B1

反応ノート

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