Hydrochloric Acid → 2-(N'-(4-hydroxyphenyl)ureido)ethylmethacrylate

HRID 1070371

反応式

HRID 1070371 の反応式
[CH:1]1[C:6]([NH2:7])=[CH:5][CH:4]=[C:3]([OH:8])[CH:2]=1.[C:9]([O:14][CH2:15][CH2:16][N:17]=[C:18]=[O:19])(=[O:13])[C:10]([CH3:12])=[CH2:11].[N-]=C=O.Cl>O.CN(C)C(=O)C>[C:9]([O:14][CH2:15][CH2:16][NH:17][C:18]([NH:7][C:6]1[CH:5]=[CH:4][C:3]([OH:8])=[CH:2][CH:1]=1)=[O:19])(=[O:13])[C:10]([CH3:12])=[CH2:11]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 4034-AminophenolHCID 354092-Isocyanatoethyl methacrylateHCID 105034Isocyanate

生成物 1

HCID 228923762-(N'-(4-hydroxyphenyl)ureido)ethylmethacrylate収率 93.3%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 31374Dimethylacetamide溶媒

実験手順

Into a 1 liter fask 500 g of N,N-Dimethyl acetamide and 173.5 g (1.6 mole) of p-aminophenol were added. This mixture was placed in cold bath and 234.9 g (1.5 mole) of methacryloyl oxyethyl isocyanate was added over a period of 1 hour. After the addition was complete, stirring was continued for 5 hours at room temperature. The mixture was tested for isocyanate functionality using IR spectroscopy. 30 ml of concentrated HCl was added to the mixture and was stirred for 15 minutes. The mixture was poured into 4.5 liter of water. The deposit was filtered, washed and dried to produce 370 g of 2-(N′-(4-hydroxyphenyl)ureido)ethyl methacrylate.

後処理

  1. customThis mixture was placed in cold bath
  2. additionAfter the addition
  3. stirringwas stirred for 15 minutes
  4. filtrationThe deposit was filtered
  5. washwashed
  6. customdried

出典と根拠

ORDレコード
ord-6b78b2288e58467b9dc04b0bfa0cbd18
出典データセット
uspto-grants-2005_06
特許番号
US06902860B2

関連ノート

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