化工社化工社 化学情報印刷レポート · 研究参考用
Furan → (3,5-Dioxo-10-oxa-4-azatricyclo[5.2.1.02,6]dec-4-yl)acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Furan | HCID 8029 | — |
| 反応物 | Maleimide | HCID 10935 | — |
| 反応物 | Bromoacetonitrile | HCID 11534 | — |
| 反応物 | 10-Oxa-4-azatricyclo(5.2.1.02,6)decane-3,5-dione | HCID 239727 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (3,5-Dioxo-10-oxa-4-azatricyclo[5.2.1.02,6]dec-4-yl)acetonitrile | HCID 22396537 | — |
反応手順
Synthesis took place in analogy to Example VI a from 10-oxa-4-azatricyclo[5.2.1.02,6]decane-3,5-dione (obtainable from maleimide and furan from Diels-Alder reaction for example as described by Padwa, A.; Dimitroff, M.; Waterson, A. G.; Wu, T.; J Org Chem 1997, 62, 4088-4096 and subsequent hydrogenation as described by Ansell, M. F.; Caton, M. P. L.; North, P. C.; Tetrahedron Lett. 1982, 23, 2811) and bromoacetonitrile with the exception that acetone was used as solvent in place of DMF. The substance was employed as crude product in the next reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06903089B1 |
| 出典データセット | uspto-grants-2005_06 |
| ORD ID | ord-5397b9d01bdc473a8cd5f7b98554a071 |
| 出典メモ | uspto-grants-2005_06 |