3,4-Dichlorobenzyl chloride → 3,4-dichlorobenzyl-4-piperidone

HRID 1070488ノート

反応式

HRID 1070488 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5]Cl.O.Cl.[O:13]=[C:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(N(CC)CC)C>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][N:17]1[CH2:18][CH2:19][C:14](=[O:13])[CH2:15][CH2:16]1

参加物

5

反応物 3

HCID 76093,4-Dichlorobenzyl chlorideHCID 8471TriethylamineHCID 2723901Piperonylamine

生成物 1

HCID 108487763,4-dichlorobenzyl-4-piperidone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 3,4-dichlorobenzyl chloride (2.8 ml), 4-ketopiperidine hydrochloride monohydrate and triethylamine (8 ml) in dimethylformamide (30 ml) was stirred at room temperature for 20 h. The mixture was partitioned between water and ethyl acetate, the organic layer dried and evaporated under reduced pressure. Purification was by chromatography eluting with 40-50% ethyl acetate/isohexane. Yield 2.1 g.

後処理

  1. customThe mixture was partitioned between water and ethyl acetate
  2. customthe organic layer dried
  3. customevaporated under reduced pressure
  4. customPurification
  5. washeluting with 40-50% ethyl acetate/isohexane

出典と根拠

ORDレコード
ord-659355a251114a28b73fe0c6bc1705bb
出典データセット
uspto-grants-2005_06
特許番号
US06903085B1

反応ノート

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