N-BOC-ethylenediamine → HCID 22396192、化合物

HRID 1070489ノート

反応式

HRID 1070489 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[Cl:16])[CH2:5][N:6]1[CH2:11][CH2:10][C:9](=O)[CH2:8][CH2:7]1.[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26][NH2:27])=[O:23])([CH3:20])([CH3:19])[CH3:18].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCl>[C:17]([O:21][C:22](=[O:23])[NH:24][CH2:25][CH2:26][NH:27][CH:9]1[CH2:10][CH2:11][N:6]([CH2:5][C:4]2[CH:13]=[CH:14][C:15]([Cl:16])=[C:2]([Cl:1])[CH:3]=2)[CH2:7][CH2:8]1)([CH3:20])([CH3:18])[CH3:19]

参加物

5

反応物 3

HCID 187201N-BOC-ethylenediamineHCID 5049666Sodium triacetoxyborohydrideHCID 108487763,4-dichlorobenzyl-4-piperidone

生成物 1

HCID 22396192HCID 22396192、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of the product from step (i) (1.61 g), N-(tert-butoxycarbonyl)-ethylenediamine (1 g) and sodium triacetoxyborohydride (2.12 g) in dichloromethane (20 ml) was stirred at room temperature for 3 h. The mixture was partitioned between water and ethyl acetate, the organic layer dried and evaporated under reduced pressure. Yield 1.28 g.

後処理

  1. customThe mixture was partitioned between water and ethyl acetate
  2. customthe organic layer dried
  3. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-580f275b589746b4bc43ed6206780079
出典データセット
uspto-grants-2005_06
特許番号
US06903085B1

反応ノート

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