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4-Chlorobenzylamine → Diethyl 2-(((4-Chlorobenzyl)amino)carbonyl)malonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorobenzylamine | HCID 66036 | — |
| 反応物 | Triethyl methanetricarboxylate | HCID 80471 | — |
| 生成物 | Diethyl 2-(((4-Chlorobenzyl)amino)carbonyl)malonate | HCID 22397146 | 30.5% |
反応手順
Triethyl methanetricarboxylate (2.32 g) and 4-chlorobenzylamine (1.42 g) are stirred at room temperature for 16 h. Insoluble material is filtered off and the filtrate is purified by column chromatography (hexanes/acetone, 5/1) to give 1 g (12%) of the title compound as an oil which slowly solidifies. Physical characteristics: MS (ESI+) m/z 330 (M+H)+. 1H NMR (CDCl3) δ7.70, 7.31, 7.26, 4.48, 4.38, 4.28, 1.30.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06903097B2 |
| 出典データセット | uspto-grants-2005_06 |
| ORD ID | ord-8dccb9adee8b407f9437ffe4a4f02d57 |
| 出典メモ | uspto-grants-2005_06 |