Isobutyryl chloride → 6,7-Dimethoxy-2-isobutyrylnaphthalene

HRID 1070668ノート

反応式

HRID 1070668 の反応式
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.[C:15](Cl)(=[O:19])[CH:16]([CH3:18])[CH3:17].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[CH3:14][O:13][C:12]1[CH:11]=[C:10]2[C:5](=[CH:4][C:3]=1[O:2][CH3:1])[CH:6]=[C:7]([C:15](=[O:19])[CH:16]([CH3:18])[CH3:17])[CH:8]=[CH:9]2

参加物

5

反応物 3

HCID 62325Isobutyryl chlorideHCID 6047082,3-DimethoxynaphthaleneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 114142376,7-Dimethoxy-2-isobutyrylnaphthalene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The solution of 2,3-dimethoxynaphthalene (16.5 g ), isobutyroylchloride (12.5 g) and aluminum chloride (15.7 g) in methylene chloride (200 ml) was stirred at ambient temperature overnight. The solution was then washed with saturated sodium bicarbonate and water, dried with sodium sulfate and evaporated. Finally the crude product was triturated with ether. Yield: 13.5 g, melting point 103-105° C.

後処理

  1. washThe solution was then washed with saturated sodium bicarbonate and water
  2. dry with materialdried with sodium sulfate
  3. customevaporated
  4. customFinally the crude product was triturated with ether

出典と根拠

ORDレコード
ord-73fdc15dc46c40ffafb067fddaaf97bf
出典データセット
uspto-grants-2005_06
特許番号
US06903114B2

反応ノート

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