化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → 1,2,3,6-Tetrahydro-4-(3-(methylthio)phenyl)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic acid tert-butyl ester | HCID 12988964 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1,2,3,6-Tetrahydro-4-(3-(methylthio)phenyl)pyridine | HCID 12988965 | — |
反応手順
4-Hydroxy-4-(3-methylsulfanyl-phenyl)-piperidin-1-carboxylic acid tert-butyl ester (3.97 g) was dissolved in CH2Cl2 (500 ml) and trifluoroacetic acid (80 ml) was added in one portion. The mixture was refluxed for one hour and then washed with two portions of 10%-Na2CO3, dried (MgSO4), filtered and evaporated to dryness. Yield 2.07 g. MS m/z (relative intensity, 70 eV) 205 (M+, 73), 158 (44), 129 (95), 128 (80), 82 (bp).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06903120B2 |
| 出典データセット | uspto-grants-2005_06 |
| ORD ID | ord-f48fb305a3294b1f9a93eac92aa73217 |
| 出典メモ | uspto-grants-2005_06 |