Benzyl Bromide → 6-[[2-Benzylmercapto-1-(4-methylphenyl)-1H-benzimidazol-6-yl]oxy]Hexanoic Acid Methyl Ester

HRID 1070852

反応式

HRID 1070852 の反応式
[CH3:1][O:2][C:3](=[O:27])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([SH:18])[N:15]([C:19]3[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=3)[C:14]=2[CH:26]=1.[CH2:28](Br)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.C(=O)([O-])O.[K+].C1CC2OCCOCCOC3C(OCCOCCOC2CC1)CCCC3>CN(C)C=O>[CH3:1][O:2][C:3](=[O:27])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([S:18][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:15]([C:19]3[CH:20]=[CH:21][C:22]([CH3:25])=[CH:23][CH:24]=3)[C:14]=2[CH:26]=1

参加物

6

反応物 4

HCID 7498Benzyl BromideHCID 85955Dicyclohexano-18-crown-6HCID 516893Potassium BicarbonateHCID 178500330HCID 178500330、化合物

生成物 1

HCID 101625126-[[2-Benzylmercapto-1-(4-methylphenyl)-1H-benzimidazol-6-yl]oxy]Hexanoic Acid Methyl Ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
20 °C

実験手順

800 mg of 6-[[2-mercapto-1-(4-methylphenyl)-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester was dissolved in 8 ml of N,N-dimethylformamide, mixed with 0.3 ml of benzylbromide, 438 mg of potassium hydrogen carbonate and 75 mg of dicyclohexano-18-crown-6, and the mixture was stirred for 15 hours at 20° C. It was filtered, and the filtrate was concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 976 mg was obtained.

後処理

  1. filtrationIt was filtered
  2. concentrationthe filtrate was concentrated by evaporation in a vacuum
  3. customThe residue was purified by column chromatography on silica gel
  4. custom976 mg was obtained

出典と根拠

ORDレコード
ord-2118528183b0490796652adc28040645
出典データセット
uspto-grants-2005_06
特許番号
US06903126B2

関連ノート

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