4-Acetylbenzenesulphonamide → 4-{3E-[2-(3-Hydroxy-2-hydroxymethyl-propoxy)-4-methoxy-5-thiophen-2-yl-phenyl]-acryloyl}-benzenesulfonamide

HRID 10709

反応式

HRID 10709 の反応式
[OH:1][CH2:2][CH:3]([CH2:21][OH:22])[CH2:4][O:5][C:6]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][C:7]=1[CH:8]=O.[C:23]([C:26]1[CH:31]=[CH:30][C:29]([S:32]([NH2:35])(=[O:34])=[O:33])=[CH:28][CH:27]=1)(=[O:25])[CH3:24].C[O-].[Li+]>CN(C)C=O.CO.O>[OH:1][CH2:2][CH:3]([CH2:21][OH:22])[CH2:4][O:5][C:6]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][C:7]=1/[CH:8]=[CH:24]/[C:23]([C:26]1[CH:27]=[CH:28][C:29]([S:32]([NH2:35])(=[O:34])=[O:33])=[CH:30][CH:31]=1)=[O:25]

参加物

6

反応物 3

HCID 740654-AcetylbenzenesulphonamideHCID 4177230Lithium methanolateHCID 161159082-(3-Hydroxy-2-hydroxymethylpropoxy)-4-methoxy-5-thien-2-ylbenzaldehyde

生成物 1

HCID 104137674-{3E-[2-(3-Hydroxy-2-hydroxymethyl-propoxy)-4-methoxy-5-thiophen-2-yl-phenyl]-acryloyl}-benzenesulfonamide収率 60%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 21901440N,N-dimethylformamide methanol溶媒

実験手順

2-(3-Hydroxy-2-hydroxymethyl-propoxy)-4-methoxy-5-thiophen-2-yl-benzaldehyde (Ex-64B) (8.0 g, 24.8 mmol) and 4-acetylbenzenesulfonamide (4.9 g, 24.8 mmol) were dissolved in a dimethylformamide-methanol solution (170 mL, 7:3). After complete dissolution, lithium methoxide (3.8 g, 99.2 mmol) was added and the resulting red-orange slurry was stirred in the dark at room temperature for 3 h. Upon completion, as determined by HPLC, the mixture was diluted with water (500 mL) and extracted with ethyl acetate (6×200 mL). The combined organic extracts were dried over sodium sulfate and evaporated to dryness. The crude oil was taken up in ethanol (150 mL) and warmed to 60° C. to obtain complete dissolution and allowed to cool to room temperature. The resulting precipitate was collected on filter paper and dried in vacuo to yield 7.0 g (60%) of the title compound as a light orange solid, mp 123–124° C. 1H-NMR (300 MHz, DMSO-d6) δ 8.25–8.29 (m, 3H), 7.90–8.11 (m, 4H), 7.66 (d, 1H, J=3.0 Hz), 7.56 (brs, 1H), 7.52 (d, 1H, J=5.1 Hz), 7.13 (dd, 1H, J=5.1, 3.0 Hz), 6.88 (s, 1H), 4.67 (t, 2H, J=10.8 Hz), 4.24 (d, 2H, J=6.0 Hz), 4.00 (s, 3H), 3.54–3.65 (m, 4H), 2.09–2.13 (m, 1H). MS (ESI) m/z=504 ([M+H]+, 100%). Anal. Calcd. C24H25NO7S2H2O: C, 57.24; H, 5.00; N, 2.78; S, 12.73. Found: C, 56.72; H, 5.27; N, 2.71; S, 12.11.

後処理

  1. additionwas added
  2. extractionextracted with ethyl acetate (6×200 mL)
  3. dry with materialThe combined organic extracts were dried over sodium sulfate
  4. customevaporated to dryness
  5. temperaturewarmed to 60° C.
  6. customto obtain complete
  7. dissolutiondissolution
  8. temperatureto cool to room temperature
  9. customThe resulting precipitate was collected
  10. filtrationon filter paper
  11. customdried in vacuo

出典と根拠

ORDレコード
ord-d5d0065b0beb4a9089063d96da5c0eb4
出典データセット
uspto-grants-2006_08
特許番号
US07094801B2

関連ノート

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