6-Fluoroimidazo[1,2-a]pyridine-2-carboxylic acid → 5-Methylimidazo[1,2-a]pyridine-2-carboxylic acid

HRID 1070938ノート

反応式

HRID 1070938 の反応式
F[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=2)[CH:7]=1.[CH2:14]([O:16][C:17]([C:19]1[NH:20][CH:21]2[CH:26]=[CH:25][CH:24]=[C:23]([CH3:27])[N:22]2[CH:28]=1)=[O:18])[CH3:15]>>[CH3:27][C:23]1[N:22]2[CH:28]=[C:19]([C:17]([OH:18])=[O:16])[N:20]=[C:21]2[CH:26]=[CH:25][CH:24]=1.[CH3:14][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=2)[CH:7]=1.[CH2:14]([O:16][C:17]([C:19]1[N:20]=[C:21]2[CH:26]=[CH:25][C:24]([CH3:2])=[CH:23][N:22]2[CH:28]=1)=[O:18])[CH3:15]

参加物

5

反応物 2

HCID 223975086-Fluoroimidazo[1,2-a]pyridine-2-carboxylic acid2 回HCID 694322985-Methyl-1,8a-dihydro-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

生成物 3

HCID 20621695-Methylimidazo[1,2-a]pyridine-2-carboxylic acidHCID 27598636-Methylimidazo[1,2-a]pyridine-2-carboxylic acidHCID 12558372Ethyl 6-methylimidazo(1,2-a)pyridine-2-carboxylate

実験手順

5-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid was prepared in a similar manner to 6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid (see Example 25) using the commercially available 5-methyl-1,8a-dihydro-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester. 6-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid and 6-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester were prepared in a similar manner to 6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid and its ester above.

出典と根拠

ORDレコード
ord-ab89e9ca34bb40fe903cf215b5456f93
出典データセット
uspto-grants-2005_06
特許番号
US06903115B2

反応ノート

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