HCID 22393544、化合物 → HCID 22393533、化合物
反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-])=O)[C:7](=[O:14])[NH:6][CH2:5]2>C(OCC)(=O)C>[NH2:11][C:10]1[CH:9]=[C:8]2[C:4]([CH2:5][NH:6][C:7]2=[O:14])=[CH:3][C:2]=1[CH3:1]参加物
3
実験手順
5-Methyl-6-nitro-2,3-dihydro-isoindol-1-one (100.00 mg, 0.52 mmol) was taken up in ethyl acetate in a Paar vessel and flushed with argon. Palladium on carbon (25 mg) was added and the argon atmosphere was replaced with hydrogen at 50 psi. The vessel was shaken for 12 h. The hydrogen was then replaced with argon and the catalyst was removed by filtration through celite. The solvent was removed under reduced pressure to yield 65.8 mg of the desired amine. C9H10N2O MS m/e=163.2 (M+H).
後処理
- customflushed with argon
- additionPalladium on carbon (25 mg) was added
- customthe catalyst was removed by filtration through celite
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-cc4fa0ef5f1744418518e2d38bfd1209
- 出典データセット
- uspto-grants-2005_06
- 特許番号
- US06906067B2
反応ノート
読み込み中…