2,2,2-trifluoro-N-(2-methyl-5-nitrophenyl)acetamide → N-(5-Amino-2-methyl-phenyl)-2,2,2-trifluoro-acetamide

HRID 1071524ノート

反応式

HRID 1071524 の反応式
[F:1][C:2]([F:17])([F:16])[C:3]([NH:5][C:6]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[CH:8][C:7]=1[CH3:15])=[O:4]>C(OCC)(=O)C>[NH2:12][C:10]1[CH:9]=[CH:8][C:7]([CH3:15])=[C:6]([NH:5][C:3](=[O:4])[C:2]([F:1])([F:16])[F:17])[CH:11]=1

参加物

3

反応物 1

HCID 8307252,2,2-trifluoro-N-(2-methyl-5-nitrophenyl)acetamide

生成物 1

HCID 22393536N-(5-Amino-2-methyl-phenyl)-2,2,2-trifluoro-acetamide収率 95%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

2,2,2-Trifluoro-N-(2-methyl-5-nitro-phenyl)-acetamide (3.91 g, 15.78 mmol) was taken up in ethyl acetate in a Paar vessel and flushed with argon. Palladium on carbon (400 mg) was added and the argon atmosphere was replaced with hydrogen at 50 psi. The vessel was shaken for 12 h. The hydrogen was then replaced with argon and the catalyst was removed by filtration through celite. The solvent was removed under reduced pressure to yield 3.27 g of the desired amine. C9H9F3N2O MS m/e=219.1 (M+H).

後処理

  1. customflushed with argon
  2. additionPalladium on carbon (400 mg) was added
  3. customthe catalyst was removed by filtration through celite
  4. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-79fc51b4576348d39ad160ac8c538be5
出典データセット
uspto-grants-2005_06
特許番号
US06906067B2

反応ノート

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