Ethyl Acetate → 2-(3-Amino-4-methyl-benzyl)-isoindole-1,3-dione

HRID 1071529ノート

反応式

HRID 1071529 の反応式
C[CH:2]([N:12]1[C:20](=[O:21])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:22])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-])=O)[CH:4]=1.[C:23](OCC)(=O)C>>[NH2:9][C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][C:6]=1[CH3:23])[CH2:2][N:12]1[C:13](=[O:22])[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:20]1=[O:21]

参加物

3

反応物 2

HCID 8857Ethyl AcetateHCID 223935242-(Methyl-3-nitro-benzyl)-isoindole-1,3-dione

生成物 1

HCID 223935232-(3-Amino-4-methyl-benzyl)-isoindole-1,3-dione

実験手順

2-(Methyl-3-nitro-benzyl)-isoindole-1,3-dione (0.45 g, 1.52 mmol) was taken up in ethyl acetate in a Paar vessel and flushed with argon. Palladium on carbon (100 mg) was added and the argon atmosphere was replaced with hydrogen at 50 psi. The vessel was shaken for 12 h. The hydrogen was then replaced with argon and the catalyst was removed by filtration through celite. The solvent was removed under reduced pressure to yield 0.40 g of the desired amine. C16H14N2O2 MS m/e=267.3 (M+H).

後処理

  1. customflushed with argon
  2. additionPalladium on carbon (100 mg) was added
  3. customthe catalyst was removed by filtration through celite
  4. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-a718e1c175bb4189b09e0165d6494cc2
出典データセット
uspto-grants-2005_06
特許番号
US06906067B2

反応ノート

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