Sulfuric Acid → Benzenamine, 2-[(1H-benzimidazol-2-ylthio)methyl]-

HRID 1071530ノート

反応式

HRID 1071530 の反応式
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH2:11][C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14]O.S(=O)(=O)(O)O.O.C1(N)C=CC=CC=1.C1(N)C=CC=CC=1>C(O)(=O)C>[NH:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[S:1][CH2:14][C:13]1[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=1[NH2:11]

参加物

6

反応物 4

HCID 1118Sulfuric Acid2 回HCID 214392-Aminobenzyl alcohol2 回HCID 69793239HCID 69793239、化合物HCID 178527775HCID 178527775、化合物

生成物 1

HCID 11054238Benzenamine, 2-[(1H-benzimidazol-2-ylthio)methyl]-

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 9.0 g (60 mmole) of 2-mercaptobenzimidazole and 4.9 g (40 mmole) of 2-aminobenzyl alcohol were heated at 84° C. in a mixture of 45 ml of glacial acetic acid and 12.0 g (120 mmole) of sulfuric acid. After two hours an additional 1 g (8 mmole) of 2-aminobenzyl alcohol and 1 g of sulfuric acid were added. After one hour the reaction mixture was cooled and poured into cold benzenamine hemihydrate.

後処理

  1. temperatureAfter one hour the reaction mixture was cooled

出典と根拠

ORDレコード
ord-063e73f08b79453a9efc53dbf18adaa2
出典データセット
uspto-grants-2005_06
特許番号
US06906078B2

反応ノート

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