2-(Chloromethyl)aniline hydrochloride → 2-[[(5,6-Dimethyl-1H-benzimidazol-2-yl)thio]methyl]benzenamine

HRID 1071534ノート

反応式

HRID 1071534 の反応式
[CH3:1][C:2]1[C:11]([CH3:12])=[CH:10][C:5]2[N:6]=[C:7]([SH:9])[NH:8][C:4]=2[CH:3]=1.Cl.Cl[CH2:15][C:16]1[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=1[NH2:18]>>[CH3:12][C:11]1[C:2]([CH3:1])=[CH:3][C:4]2[NH:8][C:7]([S:9][CH2:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[NH2:18])=[N:6][C:5]=2[CH:10]=1

参加物

3

反応物 2

HCID 123879412-(Chloromethyl)aniline hydrochlorideHCID 178422342HCID 178422342、化合物

生成物 1

HCID 137541362-[[(5,6-Dimethyl-1H-benzimidazol-2-yl)thio]methyl]benzenamine

実験手順

The title compound was prepared by the method of Example 1 using 2.56 g of 5,6-dimethyl-2-mercaptobenzimidazole instead of 2-mercaptobenzimidazole and 2.56 g of 2-(chloromethyl) aniline hydrochloride instead of 2-(chloromethyl)-N,N-dimethylaniline. Instead of using sodium carbonate in an extraction, the crude precipitate was neutralized with triethylamine in methanol. Trituration of the resultant crude title compound with methanol and diethyl ether gave 2.0 g of analytically pure title compound. Analysis. Calc'd. for C15H15N3S: C, 67.81; H, 6.05; N,14.83; S, 11.31. Found: C, 67.21; H, 6.16; N, 14.50; S, 11.06.

後処理

  1. extractionInstead of using sodium carbonate in an extraction

出典と根拠

ORDレコード
ord-c2ad029856124bdbbcd4aa8131cc1fb6
出典データセット
uspto-grants-2005_06
特許番号
US06906078B2

反応ノート

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