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Sulfuric Acid → Benzidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 2-Nitrobenzenesulphonic acid | HCID 6664 | — |
| 反応物 | Nitrobenzene | HCID 7416 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Hydrazobenzene | HCID 31222 | — |
| 反応物 | Sodium 3-nitrobenzenesulfonate | HCID 31389 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 生成物 | Benzidine | HCID 7111 | — |
反応手順
A 2-nitrobenzenesulfonic acid derivative (e.g. sodium 2-nitrobenzenesulfonate) or a 3-nitrobenzenesuflonic acid derivative (e.g. sodium 3-nitrobenzenesulfonate) and nitrobenzene are treated with zinc dust in the presence of an alkali (e.g. sodium hydroxide) and the resulting hydrazobenzene derivative is treated with sulfuric acid, to give the corresponding 4,4′-diaminobiphenyl derivative. This is diazotized using sodium nitrite under acidic conditions in the presence of hydrochloric acid, followed by reaction with sodium azide, to give the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06908719B1 |
| 出典データセット | uspto-grants-2005_06 |
| ORD ID | ord-c9827427759e481e95f5eb7980b46efa |
| 出典メモ | uspto-grants-2005_06 |