Bromine → 2-Bromo-1-[3-(3-chloro-propoxy)-phenyl]-ethanone

HRID 1072022

反応式

HRID 1072022 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12](=[O:14])[CH3:13])[CH:9]=[CH:10][CH:11]=1.[Br:15]Br.C(=O)(O)[O-].[Na+]>CCOCC>[Br:15][CH2:13][C:12]([C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([O:5][CH2:4][CH2:3][CH2:2][Cl:1])[CH:7]=1)=[O:14]

参加物

5

反応物 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 143487521-[3-(3-Chloropropoxy)phenyl]ethanone

生成物 1

HCID 220155922-Bromo-1-[3-(3-chloro-propoxy)-phenyl]-ethanone

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of the product of Step A (2.1 g) in ether (11 mL) was treated with bromine (0.53 mL) and the mixture stirred for 26 hours. The mixture was poured into saturated sodium bicarbonate solution (50 mL) and the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (50 mL) and the combined organic layers were washed with brine (50 mL), dried over magnesium sulfate, filtered, and evaporated to yield the title compound (2.8 g).

後処理

  1. customthe organic layer was separated
  2. washThe aqueous layer was washed with a fresh portion of ether (50 mL)
  3. washthe combined organic layers were washed with brine (50 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-5220811f4e594906a0764a34a05dfce3
出典データセット
uspto-grants-2005_06
特許番号
US06908929B2

関連ノート

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