Bromine → alpha-Bromo-2'-fluoro-4'-chloropropoxyacetophenone

HRID 1072028ノート

反応式

HRID 1072028 の反応式
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])[CH:5]=[CH:4][C:3]=1[C:13](=[O:15])[CH3:14].[Br:16]Br.C(=O)(O)[O-].[Na+]>CCOCC>[Br:16][CH2:14][C:13]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])=[CH:7][C:2]=1[F:1])=[O:15]

参加物

5

反応物 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 693758382'-Fluoro-4'-chloropropoxyacetophenone

生成物 1

HCID 22015593alpha-Bromo-2'-fluoro-4'-chloropropoxyacetophenone

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of the product of Step A (2.3 g) in ether (10 mL) was treated with bromine (0.51 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (40 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (40 mL). The combined organic layers were washed with a fresh portion of water (50 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (3.1 g).

後処理

  1. customthe organic layer was separated
  2. washThe aqueous layer was washed with a fresh portion of ether (40 mL)
  3. washThe combined organic layers were washed with a fresh portion of water (50 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-6b55dccd5c954e5d98951512d70960b1
出典データセット
uspto-grants-2005_06
特許番号
US06908929B2

反応ノート

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