Epichlorohydrin → 2-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

HRID 1072047ノート

反応式

HRID 1072047 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][N:11]3[CH:17]=2)=[CH:4][CH:3]=1.[OH-].[K+].[CH2:20]([CH:22]1[O:24][CH2:23]1)Cl>CO.ClCCl>[O:24]1[CH2:23][CH:22]1[CH2:20][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]3[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][N:11]3[CH:17]=2)=[CH:6][CH:7]=1

参加物

6

反応物 3

HCID 7835EpichlorohydrinHCID 14797Potassium HydroxideHCID 220156592-[4-Hydroxyphenyl]-8-methylimidazo[1,2-a]pyridine

生成物 1

HCID 220156322-[4-[(2,3-Epoxy)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

The product of Step B (27 g) in methanol (500 mL) was treated with potassium hydroxide (14 g) and stirred at ambient temperature for 2 hours. To this solution was then added epichlorohydrin (9.4 mL) and the mixture stirred for an additional 48 hours. The reaction mixture was diluted with dichloromethane, filtered and the filtrate washed with water, dried, sodium sulfate filtered and evaporated to afford the title compound (18.2 g).

後処理

  1. filtrationfiltered
  2. washthe filtrate washed with water
  3. customdried
  4. filtrationsodium sulfate filtered
  5. customevaporated

出典と根拠

ORDレコード
ord-6ffc745b508f491d9a07d73c21247d50
出典データセット
uspto-grants-2005_06
特許番号
US06908929B2

反応ノート

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