6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol → 7-Deazahypoxanthine

HRID 1072128

反応式

HRID 1072128 の反応式
[NH2:1][C:2]1[N:7]=[CH:6][NH:5][C:4](=[O:8])[C:3]=1[CH2:9][CH:10](OCC)OCC>Cl>[N:7]1[C:2]2[NH:1][CH:10]=[CH:9][C:3]=2[C:4](=[O:8])[NH:5][CH:6]=1

参加物

3

反応物 1

HCID 1354086886-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol

生成物 1

HCID 1354086897-Deazahypoxanthine収率 64%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

6-Amino-5-(2,2-diethoxy-ethyl)-3H-pyrimidin-4-one (150 mg, 0.7 mmol) was dissolved in 5.0 mL of 1N HCl solution. The mixture was stirred at room temperature for 1 hour and the precipitate was filtered, washed with minimal amount of water and dried in a vacuum oven overnight to give 60 mg (64%) of 3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one as a white solid. 1H NMR (360 MHz, DMSO-d6) δ 11.83 (s, 1H, NH), 1.75 (s, 1H, NH), 7.80 (s, 1H), 7.01 (dd, J=2.65, 3.21 Hz, 1H), and 6.42 (dd, J=2.09, 3.21 Hz, 1H). MS m/e 134 [M+1]+.

後処理

  1. filtrationthe precipitate was filtered
  2. washwashed with minimal amount of water
  3. customdried in a vacuum oven overnight

出典と根拠

ORDレコード
ord-54d454d47bba4e13922dc52ba7c4ca4d
出典データセット
uspto-grants-2005_06
特許番号
US06908930B2

関連ノート

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