Trimethyl orthoacetate → 5-Bromo-2-methyl-1,3-benzoxazole
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[OH:9].[C:10](OC)(OC)(OC)[CH3:11]>>[CH3:10][C:11]1[O:9][C:3]2[CH:4]=[CH:5][C:6]([Br:8])=[CH:7][C:2]=2[N:1]=1参加物
3
実験手順
A solution of 2-amino-4-bromophenol (1 g, 5.32 mmol) in trimethyl orthoacetate (20 mL) was refluxed for 1.5 hours. The reaction was then cooled and the solvent removed under reduced pressure to give 1.1 g of title compound.
後処理
- temperatureThe reaction was then cooled
- customthe solvent removed under reduced pressure
出典と根拠
- ORDレコード
- ord-900f703f86434b4394847e71afa5172c
- 出典データセット
- uspto-grants-2005_06
- 特許番号
- US06908935B2
反応ノート
読み込み中…