1-Phenethylamine, (+)- → ((1R)-1-Phenylethyl){[4-methoxy-3-(5-methoxy(3-pyridyl)) phenyl]methyl}amine

反応式

[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][C:4]=1[C:11]1[CH:12]=[N:13][CH:14]=[C:15]([O:17][CH3:18])[CH:16]=1.[CH3:19][C@@H:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:21]1([C@H:20]([NH:27][CH2:7][C:6]2[CH:9]=[CH:10][C:3]([O:2][CH3:1])=[C:4]([C:11]3[CH:12]=[N:13][CH:14]=[C:15]([O:17][CH3:18])[CH:16]=3)[CH:5]=2)[CH3:19])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

参加物

反応物 2

HCID 6431891-Phenethylamine, (+)-

HCID 223912194-Methoxy-3-(5-methoxypyridin-3-yl)benzaldehyde

生成物 1

HCID 60010341((1R)-1-Phenylethyl){[4-methoxy-3-(5-methoxy(3-pyridyl)) phenyl]methyl}amine

実験手順

The title compound (0.8 g, white solid as HCl salt) was prepared from 4-methoxy-3-(5-methoxy(3-pyridyl))benzaldehyde (0.71 g) and (R)-α-methylbenzylamine (0.371 mL) analogously to Example 66, step 3.

出典と根拠

ORDレコード: ord-003c698bf1a9493e8c8097a8dcc67c3d
出典データセット: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06908935B2

反応ノート

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