Cetirizine → Cetirizine Hydrochloride

HRID 1072260

反応式

HRID 1072260 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][O:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:17][CH2:16]2)[C:8]2[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[CH:5][CH:6]=1>ClCCl>[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][O:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:17][CH2:16]2)[C:8]2[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[CH:5][CH:6]=1.[ClH:14].[ClH:14]

参加物

3

反応物 1

HCID 2678Cetirizine

生成物 1

HCID 55182Cetirizine Hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A further possibility is that—after the hydrolysis and adjustment of the pH value to 3.8-4.0—the solution of cetirizine base in dichloromethane is extracted with preferably 5-30% hydrochloric acid, the aqueous solution is concentrated under reduced pressure to reduce the water content to 20-25% by mass and then the procedure described above is followed to obtain cetirizine dihydrochloride.

後処理

  1. extractionis extracted with preferably 5-30% hydrochloric acid
  2. concentrationthe aqueous solution is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-52466298a7c44df7a3de492f5a0d091d
出典データセット
uspto-grants-2005_06
特許番号
US06908999B2

関連ノート

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