7-[(Pyridin-3-yl)hydroxymethyl]imidazo[5,1-b]thiazole → 7-(Pyridin-3-yl)carbonylimidazo[5,1-b]thiazole

HRID 1072323ノート

反応式

HRID 1072323 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([OH:16])[C:8]2[N:9]=[CH:10][N:11]3[CH:15]=[CH:14][S:13][C:12]=23)[CH:2]=1>ClCCl.[O-2].[O-2].[Mn+4]>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([C:8]2[N:9]=[CH:10][N:11]3[CH:15]=[CH:14][S:13][C:12]=23)=[O:16])[CH:2]=1

参加物

4

反応物 1

HCID 223902477-[(Pyridin-3-yl)hydroxymethyl]imidazo[5,1-b]thiazole

生成物 1

HCID 223903557-(Pyridin-3-yl)carbonylimidazo[5,1-b]thiazole収率 108.8%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

Manganese dioxide (1.0 g) was added to a solution of 1.02 g of 7-[(pyridin-3-yl)hydroxymethyl]imidazo[5,1-b]thiazole in 40 ml of dichloromethane, and the mixture was stirred at room temperature for 5 hr. The reaction solution was filtered through Celite, followed by washing with dichloromethane. The filtrate was concentrated under the reduced pressure to give 1.10 g of 7-(pyridin-3-yl)carbonylimidazo[5,1-b]thiazole.

後処理

  1. filtrationThe reaction solution was filtered through Celite
  2. washby washing with dichloromethane
  3. concentrationThe filtrate was concentrated under the reduced pressure

出典と根拠

ORDレコード
ord-9639c2456b60468f98f5c84a36f6e6e3
出典データセット
uspto-grants-2005_06
特許番号
US06908913B2

反応ノート

読み込み中…